Professor of Cancer Genomics and Data Science
David Wedge is a Professor of Cancer Genomics and Data Science at the Manchester Cancer Research Centre, University of Manchester. He was co-lead of the Evolution and Heterogeneity working group of the ICGC Pan-Cancer Analysis of Whole Genomes (PCAWG) project and is currently one of the leaders of the Pan Prostate Cancer Group.
Much of the research in the Wedge lab is focused on tumour evolution, from the initial transformation of normal cells to cancer, through the acquisition of treatment resistance and to the formation of metastatic lesions. The Wedge group have pioneered the development of computational methods to study heterogeneity in primary and metastatic cancers. Recently, the focus of the lab has shifted towards understudied populations, including the genomics of breast cancer in Nigerian women and of lung cancer in non-smokers.