The Clinical Informatics Hub supports the routine collection of real-time, real-world data as close to clinical trial quality as possible. The large scale analysis of these data generates hypotheses that can be tested in mechanistic pre-clinical studies and allows researchers to stratify patients according to their diverse characteristics and achieve individualised treatments.
At a Glance: The Clinical Informatics Hub
The Clinical Informatics Hub supports the capture of real-time, real-world clinical outcomes using patient reported outcomes measures (PROMs) and patient reported experience measures (PREMS). Working with the Digital Cancer Centre (incorporating Christie digital and the UkCAT big data infrastructure) this infrastructure underpins the co-morbidity and polypharmacy modelling in WP2, and benefits from the routine capture of electronic PROMs/PREMs that is rolling out across The Christie for all disease groups and treatment modalities. Biostatisticians and data managers within this hub support WP2 by applying mathematical and statistical modelling techniques to routine observational radiotherapy data including imaging and treatment data to inform novel small animal experiments with the ultimate aim of individualising treatment for each patient.
Research Questions: The Clinical Informatics Hub
By working with other researchers across Manchester, our researchers are seeking to answer key questions that will help improve how real-world-real-time cancer datasets are used in research. Examples of the research questions being addressed through this theme include:
- Provide secure research access to linked cancer datasets
- Develop the methodologies and infrastructure needed to realise the Learning Healthcare System concept for cancer in GM
- Enable greater precision in patient stratification and improve patient outcome for those typically underrepresented in conventional clinical trials
About CRUK RadNet Manchester
Cancer Research UK RadNet Manchester is a Radiation Research Unit in collaboration with The Christie
RadNet Facilities and Infrastructure
CRUK RadNet Manchester benefits from the existing infrastructure and facilities within Manchester across the various strategic partners of the CRUK Manchester Centre.
AHP Doctoral Academy
Providing training and development for Allied Health Professionals (AHPs) including radiographers.
Radiotherapy and Immune Cell Interactions
Discover research investigating the immunological consequences of radiotherapy, including immunotherapy and radiotherapy combinations.
Treating Complex Comorbid Patients
Discover how we are working to understand the mechanisms of the most common and detrimental side effects of radiotherapy, and how these are influenced by medications or conditions in a patients life.
Tumour Microenvironment and Genetic Instability
Discover research in RadNet Manchester aiming to improve understanding of intra-tumour heterogeneity, radioresistance and metastasis.
National Proton Beam Therapy Hub
Discover how we are leveraging cutting edge infrastructure in Manchester to develop new treatments involving proton beam therapy.
Translational and Early Phase Radiotherapy Trials Hub
Discover how we provide the support and translational research expertise to integrate biomarker science into the development of phase one feasibility studies.