Closing date: 15/03/2027
MB-PhD Studentship: What makes a STIC dangerous? Defining the determinants of progression to high-grade serous ovarian cancer
Lead Supervisors: Professor Richard Edmondon
Lead Supervisors: Dr Christine Schmidt, Dr Stefan Meyer, Dr Beth Barnes
Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027
Project Keywords: Early detection, organoids, high-grade serous ovarian cancer (HGSOC)
Research Opportunity: MB-PhD Studentship
Project Outline
Ovarian cancer, particularly high-grade serous ovarian cancer (HGSOC), is the most lethal gynaecological cancer, with a 5-year survival rate of only ~40% that has remained largely unchanged for decades. Poor survival is mainly due to advanced-stage diagnosis, but current screening tools are ineffective for early detection. At present, the only option for prevention is risk-reducing surgery to remove fallopian tubes and ovaries. There is a clear unmet need for safer strategies to detect ovarian cancer earlier.
A recent paradigm shift suggests that HGSOC often originates in the fallopian tube, beginning as pre-cancerous serous tubal intraepithelial carcinoma (STIC) lesions. These lesions take ~7 years to progress to invasive cancer, providing a wide window for early detection. However, little is known about how STIC lesions develop or the signals they release, as they are usually identified only after fallopian tube removal.
This project will investigate what makes a STIC dangerous, focusing on the impact of ageing on STIC development and progression. An in vivo CRISPR mouse model will enable initiation of STIC lesions at their physiological site of origin in young and aged animals, allowing molecular, cellular and epigenetic features associated with progression to be defined. These findings will inform organoid models of early and late STIC lesions, providing a controlled system to investigate progression-associated biology. Findings will be integrated with patient-derived samples and clinical data to ensure translational relevance. This approach will yield insights into early disease biology and inform strategies for targeted detection of ovarian cancer.
The student will gain expertise in in vivo cancer modelling, organoid culture, molecular and epigenetic profiling, proteomics and translational biomarker research. They will be embedded within a multidisciplinary ovarian cancer research programme, working across experimental models and patient-derived samples to address an important clinical challenge, while developing skills for a career in academic medicine.
Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.
About Prof. Richard Edmondon (project Lead Supervisor)
Richard Edmondson qualified in medicine from Newcastle University in 1992 and after a year of surgical training in New Zealand undertook speciality training in the Northern Deanery in Obstetrics and Gynaecology with subspecialty training in Gynaecological Oncology at the Queen Elizabeth Hospital, Gateshead. He was awarded an MD from Newcastle University in 2002 for his work investigating the biology of the ovarian surface epithelium which led to his interest in ovarian cancer.
He was appointed as a consultant in Gateshead and honorary senior lecturer in Newcastle in 2005 and in January 2014 he took up the chair of Gynaecological Oncology at the University of Manchester.
His research interests focus on ovarian cancer and how treatments can be developed and delivered to patients that will improve both survival and quality of life.
Key information
Find answers to some common questions about our MB-PhD Studentships.
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
- holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
- currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
- holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
- currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria (including English Language).
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of MB-PhD Committee and supervisory team.
The studentship covers:
- An annual stipend of £22,894 per year to help with living costs
- Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates)
- PhD project consumables and running costs, including costs for researcher development such as conferences and travel
- MBChB tuition fees at the UK/home rate (£9,250 per annum) — a total of £37,000 — with a maximum cap of £45,000 per student (plus interest where appropriate
Please speak to the MCRC Training Office regarding individual calculations as these could vary from the stated amount, dependent on how and what fees have been paid. These are conditional upon completion of MBChB and PhD components.
Here are our quick steps to apply for our MB-PhD programme:
1. Eligibility
First, you need to check you are eligible to apply for an MB-PhD. Please see the eligibility tab (below) to read all criteria.
2. Contact supervisors
We encourage you to contact the supervisor of any MB-PhD projects that you are interested in before starting your application. Having these conversations will help you to get a feel for the different research themes and projects on offer.
3. Register
Register to apply for our MB-PhD opportunities using the Postgraduate Application Portal. You must create an account to register.
4. Create a new application
When you create a new application make sure you select the following:
- Academic Career – Postgraduate Research
- Mode of Attendance – Full-time
- Program Description – search for MB-PhD and then select the MB-PhD Programme
- Under ‘Research Title’ list MB-PhD Programme. You can provide supervisor preferences/research interests in your accompanying supporting statement and these will be considered at and after interview. You can apply for a maximum of two projects.
- If you are shortlisted, you’ll be interviewed by our MB-PhD Committee and subject to your interest performance and your project/research preferences will be matched with a lead supervisor.
- For the funding resources section, please include the following information:
– Select ‘Yes’ from the drop-down
– Type of Funding: University of Manchester Scholarship
– Awarding Body: Cancer Research UK MB-PhD
– Status of Funding – Awarded
– Funding Covers – Fully Funded
– Leave the remaining boxes blank
5. Supporting documents
Your application form must be accompanied by a CV and supporting statement. You will also provide referee details (see 6. References). You do not need to add a research proposal, and can ignore this section of the application form, since your lead supervisor will have already produced this to advertise their project.
CV
This should include:
- qualifications (GCSE, A-level or equivalent, and any higher education qualifications, including grades, and your current programme)
- academic prizes, research projects, and academics interests
- extracurricular interests, and activities and positions of responsibility relevant to your application
The information you provide in your CV will be considered in relation to widening participation, and/or university access policies, to ensure that all applicants are treated fairly.
Supporting statement
This should be 1,000 words maximum and include your reason for applying to the MB-PhD programme and your interest and suitability for the project/s you are applying to (maximum two projects). You can include project/research interest/s here and these will be considered at and post-interview.
Supporting documents can be uploaded and submitted with the online application form.
If you have any issues, your supporting documents can be sent directly to the Doctoral Academy Admissions Team at admissions.doctoralacademy@manchester.ac.uk, CC’ing in mcrctraining@manchester.ac.uk.
6. References
You need to list two referees, one of which must be an academic referee from the University of Manchester, University of St Andrews Manchester-pathway or University of Leeds MBChB programme.
This could be a:
- Clinical debrief tutor
- PEP tutor
- Literature research project supervisor
- PPD tutor
Your referees will be automatically contacted by UoM Doctoral Academy when you provide their details upon application. We would recommend notifying them of application timelines in advance.
References cannot be submitted by a supervisor named on the project you are applying for.
7. Acknowledgement and review process
Once you have submitted your application form, we will email you with an acknowledgement.
We will review your application after the application deadline and once we’ve received all your supporting documents. If you are shortlised, you will be invited to attend an interview. If successful at interview, we will also share your application with a nominated supervisor(s) to review.
8. Interviews
We will email you if you are invited to interview.
Interviews will take place at the Oglesby Cancer Research Building in Withington in Spring 2026.
Applying to intercalate
UoM MBChB students must complete an intercalation Expression of Interest form by 15th January 2027 (we may be able to consider late applications to intercalate in exceptional circumstances). UoM students should contact intercalation@manchester.ac.uk for guidance.
UoL MBChB must apply to intercalate via UoL processes by January 2027.
University of St Andrews Manchester pathway students can contact mcrctraining@manchester.ac.uk for guidance.
Key dates
- Applications open: Monday 2nd November 2026
- Applications deadline: Monday 15th March 2027
- Interviews: Week commencing 3rd May 2027
- Start date: September 2027
Useful Links
Submit your application
Interested in applying for this opportunity? Submit your application on The University of Manchester application portal.
MB-PhD Studentships
Find out more about our MB-PhD Studentships which allow you to study a fully-funded PhD alongside your medical degree.
Get in Touch
Contact Yasmin Noori, Postgraduate Programme Manager.
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