What makes a STIC dangerous? Defining the determinants of progression to high-grade serous ovarian cancer

Closing date: 15/03/2027

MB-PhD Studentship: What makes a STIC dangerous? Defining the determinants of progression to high-grade serous ovarian cancer

Lead Supervisors: Professor Richard Edmondon 
Lead Supervisors: Dr Christine Schmidt, Dr Stefan Meyer, Dr Beth Barnes

Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027

Project Keywords: Early detection, organoids, high-grade serous ovarian cancer (HGSOC) 
Research Opportunity: MB-PhD Studentship

Project Outline

Ovarian cancer, particularly high-grade serous ovarian cancer (HGSOC), is the most lethal gynaecological cancer, with a 5-year survival rate of only ~40% that has remained largely unchanged for decades. Poor survival is mainly due to advanced-stage diagnosis, but current screening tools are ineffective for early detection. At present, the only option for prevention is risk-reducing surgery to remove fallopian tubes and ovaries. There is a clear unmet need for safer strategies to detect ovarian cancer earlier. 

A recent paradigm shift suggests that HGSOC often originates in the fallopian tube, beginning as pre-cancerous serous tubal intraepithelial carcinoma (STIC) lesions. These lesions take ~7 years to progress to invasive cancer, providing a wide window for early detection. However, little is known about how STIC lesions develop or the signals they release, as they are usually identified only after fallopian tube removal. 

This project will investigate what makes a STIC dangerous, focusing on the impact of ageing on STIC development and progression. An in vivo CRISPR mouse model will enable initiation of STIC lesions at their physiological site of origin in young and aged animals, allowing molecular, cellular and epigenetic features associated with progression to be defined. These findings will inform organoid models of early and late STIC lesions, providing a controlled system to investigate progression-associated biology. Findings will be integrated with patient-derived samples and clinical data to ensure translational relevance. This approach will yield insights into early disease biology and inform strategies for targeted detection of ovarian cancer. 

The student will gain expertise in in vivo cancer modelling, organoid culture, molecular and epigenetic profiling, proteomics and translational biomarker research. They will be embedded within a multidisciplinary ovarian cancer research programme, working across experimental models and patient-derived samples to address an important clinical challenge, while developing skills for a career in academic medicine. 

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Prof. Richard Edmondon (project Lead Supervisor)

Richard Edmondson qualified in medicine from Newcastle University in 1992 and after a year of surgical training in New Zealand undertook speciality training in the Northern Deanery in Obstetrics and Gynaecology with subspecialty training in Gynaecological Oncology at the Queen Elizabeth Hospital, Gateshead. He was awarded an MD from Newcastle University in 2002 for his work investigating the biology of the ovarian surface epithelium which led to his interest in ovarian cancer.

He was appointed as a consultant in Gateshead and honorary senior lecturer in Newcastle in 2005 and in January 2014 he took up the chair of Gynaecological Oncology at the University of Manchester.

His research interests focus on ovarian cancer and how treatments can be developed and delivered to patients that will improve both survival and quality of life.

Find out more

Professor-Richard-Edmondson

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