Tumour infiltrating Tregs: from zeros to heroes

Closing date: 09/03/2026

MB-PhD Studentship: Tumour infiltrating Tregs: from zeros to heroes

Lead Supervisors: Prof. Richard Edmondson
Co-Supervisors:
Prof. Adam Hurlstone, Prof. Mark Travis, Prof. Fiona Thistlethwaite

Applications Deadline: Monday 9th March 2026
Interviews: Week commencing 27th April 2026
Start date: September 2026

Project Keywords: Tregs, reprogram, TIL therapy
Research Opportunity: MB-PhD Studentship

Project Outline

Ovarian cancer remains a deadly gynaecological cancer, with nearly half of patients not surviving beyond five years despite advances in chemotherapy and maintenance treatments. Unlike some other cancers, ovarian cancer has shown very limited benefit from immune checkpoint blockade. This underlines an urgent need for innovative approaches.

One promising strategy is tumour-infiltrating lymphocyte (TIL) therapy, where a patient’s own immune cells from the tumour are expanded outside the body and reinfused to attack the cancer. While TIL therapy is now FDA-approved for advanced melanoma, early studies in ovarian cancer have produced mixed results, partly because many of the T cells in ovarian tumours are “regulatory T cells” (Tregs). These Tregs normally act as brakes on the immune system, but in ovarian cancer they accumulate in large numbers and block the immune response. Importantly, these cells are highly enriched for receptors that recognise tumour antigens — meaning that if their suppressive programme could be re-wired, they could become powerful anti-cancer effectors.

This project will explore whether patient-derived Tregs from ovarian tumours can be reprogrammed into tumour-killing cells that retain their original tumour specificity. Building on strong pilot data, the supervisory team has already established methods for isolating TILs from ovarian tumours and co-culturing with patient-derived tumour organoids, and for reprogramming Tregs using advanced techniques such as CRISPR gene editing and RNA transfection.

As a student, you will gain hands-on training in state-of-the-art laboratory skills spanning tumour immunology, gene editing, organoid models, and high-dimensional flow cytometry. You will work closely with both laboratory and clinical researchers, contributing to a highly novel project that could open an entirely new path for immunotherapy in ovarian cancer.

This is an exciting opportunity to be part of research with real translational potential, while gaining exceptional skills and mentorship for a future career in academic medicine or oncology.

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Prof. Richard Edmondson (project Lead Supervisor)

Richard Edmondson qualified in medicine from Newcastle University in 1992 and after a year of surgical training in New Zealand undertook speciality training in the Northern Deanery in Obstetrics and Gynaecology with subspecialty training in Gynaecological Oncology at the Queen Elizabeth Hospital, Gateshead. He was awarded an MD from Newcastle University in 2002 for his work investigating the biology of the ovarian surface epithelium which led to his interest in ovarian cancer.   

He was appointed as a consultant in Gateshead and honorary senior lecturer in Newcastle in 2005 and in January 2014 he took up the chair of Gynaecological Oncology at the University of Manchester. His research interests focus on ovarian cancer and how treatments can be developed and delivered to patients that will improve both survival and quality of life. 

Find out more

Professor-Richard-Edmondson

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