Translational Myeloid Haematology (MDS/AML)

Closing date: 19/06/2026

MB-PhDSummer Placement Project: Translational Myeloid Haematology (MDS/AML)

Lead Supervisors: Dr Justin Loke

Applications Deadline: Friday 19th June 2026

Project Keywords: Myeloid malignancies (MDS/AML); clonal haematopoiesis; translational haematology; haematopoietic stem cells; in vivo CRISPR genome engineering; functional genomics

Research Opportunity: MB-PhD Summer Placement Project

MB-PhD Summer Placement Project Outline

The placement is designed to show how real clinical problems in myeloid disease (risk prediction, progression, treatment resistance) are translated into tractable research questions, and how evidence flows back into molecular diagnostics, trials and patient care. 

This 1‑week, in‑person placement provides an immersive introduction to clinical and translational haematology research focused on myeloid malignancies (MDS/AML) at the CRUK Manchester Institute (Paterson Building) and The Christie Hospital.  

The student will: (1) observe a haemato‑oncology clinic and multidisciplinary team (MDT) meeting to understand patient pathways, unmet needs and how molecular diagnostics guide care; (2) to see how clinical questions are translated into experiments and studies; and (3) if desired, undertake a small, well‑defined mini‑project (e.g., analysis of a de‑identified clinical/genomic dataset or a pilot laboratory task) to learn project scoping, data handling and presentation of findings. 

Working arrangements: in person (hybrid working not required for this placement). 

 

Key activities

  • Shadow the PI and clinical nurse specialist in haemato‑oncology clinic and attend an MDT meeting. 
  • Participate in clinical/translational research meetings (study design, sample strategy, data review). 
  • Attend seminars/journal clubs and meet neighbouring groups to gain exposure to cutting‑edge cancer science. 
  • Meet clinical research fellows/registrars to discuss clinician‑scientist career routes and training opportunities. 
  • Optional mini‑project: agree a question, collect/curate a small dataset or perform a pilot assay, and deliver a short presentation/written summary at the end of the week. 

 

About Dr (Justin) Ching Loke (project Lead Supervisor)

Justin Loke is a clinician scientist and Institute Fellow at the CRUK Manchester Institute, where he is establishing his new group Myeloid Cancer Biology. He is a Consultant Haematologist at the Christie NHS Foundation Trust. His specialist interest is in the myeloid blood cancers including acute myeloid leukaemia (AML).

Find out more

Justin Loke headshot

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