Closing date: 09/03/2026
MB-PhD Studentship: Targeting RAC1 signalling to overcome KRAS inhibitor resistance in lung adenocarcinoma
Lead Supervisors: Prof. Angeliki Malliri
Co-Supervisors: Dr Colin Lindsay, Dr Martin Baker, Prof. Adam Hurlstone
Applications Deadline: Monday 9th March 2026
Interviews: Week commencing 27th April 2026
Start date: September 2026
Project Keywords: Lung adenocarcinoma, KRAS inhibitors, therapy resistance
Research Opportunity: MB-PhD Studentship
Project Outline
Lung adenocarcinoma is the most common form of non-small cell lung cancer. New precision drugs that directly inhibit mutant KRAS (for example, KRAS-G12C inhibitors) can shrink tumours, but many cancers either do not respond well or soon become resistant. One reason is that cancer cells can adopt a more mobile, treatment-tolerant state called epithelial-to-mesenchymal transition (EMT). This project aims to investigate whether mutant KRAS drives resistance by activating the RAC1 signalling pathway —a key controller of cell movement and EMT and one of the pathways activated downstream of KRAS— and if RAC1 inhibition restores sensitivity to KRAS inhibitors.
The student will explore three linked questions. First, do different KRAS mutations found in lung adenocarcinoma switch on RAC1 to different degrees? Second, which RAC1 “on-switch” proteins (GEFs) are responsible? Third, does blocking RAC1 signalling —genetically or with emerging RAC1-pathway inhibitors—improve responses to KRAS-targeted drugs and help prevent or overcome resistance?
To do this, the student will use engineered airway cell models where specific KRAS mutants can be turned on and off, together with a panel of human lung adenocarcinoma cell lines. Readouts include RAC1 activity assays, quantitative imaging, and standard viability/apoptosis assays to quantify drug response. The project builds on strong pilot data linking EMT, RAC1 activation, and decreased sensitivity to KRAS inhibitors.
The student will be embedded in the Cell Signalling Group (Oglesby Cancer Research Building), with day-to-day guidance from two experienced postdoctoral scientists and a supportive supervisory team that includes clinical and non-clinical expertise. They will gain a broad toolkit in molecular/cell biology, quantitative imaging, and drug-response analysis, present their work at conferences and publish their findings. The ultimate goal is to identify rational combination strategies and biomarkers to inform future clinical studies in KRAS-mutant lung cancer.
Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.
About Prof. Angeliki Malliri (project Lead Supervisor)
Angeliki completed her bachelor’s degree in Biology at the University of Patras and obtained her PhD from the University of Crete, Greece. She worked as a postdoctoral scientist at the CRUK Beatson Institute in Glasgow and the Netherlands Cancer Institute in Amsterdam. She established her independent research group in 2004 at CRUK Manchester Institute and moved to the Division of Cancer Sciences of the University of Manchester in March 2024.
A focus of her laboratory has been the mechanisms controlling and mediating cell migration and invasion, definitive characteristics of malignant cells essential for metastasis. For this, they have been concentrating on Rho-like GTPases and in particular the Rho-like GTPase Rac1 because of its importance in cytoskeletal organization, cell polarity, adhesion and extracellular matrix remodelling required for migration and invasion.
Key information
Find answers to some common questions about our MB-PhD Studentships.
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
- holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
- currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
- holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
- currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria (including English Language).
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of MB-PhD Committee and supervisory team.
The studentship covers:
- An annual stipend of £22,113 per year to help with living costs
- Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates)
- PhD project consumables and running costs, including costs for researcher development such as conferences and travel
- MBChB tuition fees (at the UK rate) up to a maximum of £45,000 per student inclusive of interest.
Please speak to the MCRC Training Office regarding individual calculations as these could vary from the stated amount, dependent on how and what fees have been paid. These are conditional upon completion of MBChB and PhD components.
Here are our quick steps to apply for our MB-PhD programme:
1. Eligibility
First, you need to check you are eligible to apply for an MB-PhD. Please see the eligibility tab (below) to read all criteria.
2. Contact supervisors
We encourage you to contact the supervisor of any MB-PhD projects that you are interested in before starting your application. Having these conversations will help you to get a feel for the different research themes and projects on offer.
3. Register
Register to apply for our MB-PhD opportunities using the Postgraduate Application Portal. You must create an account to register.
4. Create a new application
When you create a new application make sure you select the following:
- Academic Career – Postgraduate Research
- Mode of Attendance – Full-time
- Program Description – search for MB-PhD and then select the MB-PhD Programme
- Under ‘Research Title’ list MB-PhD Programme. You can provide supervisor preferences/research interests in your accompanying supporting statement and these will be considered at and after interview. You can apply for a maximum of two projects.
- If you are shortlisted, you’ll be interviewed by our MB-PhD Committee and subject to your interest performance and your project/research preferences will be matched with a lead supervisor.
- For the funding resources section, please include the following information:
– Select ‘Yes’ from the drop-down
– Type of Funding: University of Manchester Scholarship
– Awarding Body: Cancer Research UK MB-PhD
– Status of Funding – Awarded
– Funding Covers – Fully Funded
– Leave the remaining boxes blank
5. Supporting documents
Your application form must be accompanied by a CV and supporting statement. You will also provide referee details (see 6. References). You do not need to add a research proposal, and can ignore this section of the application form, since your lead supervisor will have already produced this to advertise their project.
CV
This should include:
- qualifications (GCSE, A-level or equivalent, and any higher education qualifications, including grades, and your current programme)
- academic prizes, research projects, and academics interests
- extracurricular interests, and activities and positions of responsibility relevant to your application
The information you provide in your CV will be considered in relation to widening participation, and/or university access policies, to ensure that all applicants are treated fairly.
Supporting statement
This should be 1,000 words maximum and include your reason for applying to the MB-PhD programme and your interest and suitability for the project/s you are applying to (maximum two projects). You can include project/research interest/s here and these will be considered at and post-interview.
Supporting documents can be uploaded and submitted with the online application form.
If you have any issues, your supporting documents can be sent directly to the Doctoral Academy Admissions Team at admissions.doctoralacademy@manchester.ac.uk, CC’ing in mcrctraining@manchester.ac.uk.
6. References
You need to list two referees, one of which must be an academic referee from the University of Manchester, University of St Andrews Manchester-pathway or University of Leeds MBChB programme.
This could be a:
- Clinical debrief tutor
- PEP tutor
- Literature research project supervisor
- PPD tutor
Your referees will be automatically contacted by UoM Doctoral Academy when you provide their details upon application. We would recommend notifying them of application timelines in advance.
References cannot be submitted by a supervisor named on the project you are applying for.
7. Acknowledgement and review process
Once you have submitted your application form, we will email you with an acknowledgement.
We will review your application after the application deadline and once we’ve received all your supporting documents. If you are shortlised, you will be invited to attend an interview. If successful at interview, we will also share your application with a nominated supervisor(s) to review.
8. Interviews
We will email you if you are invited to interview.
Interviews will take place at the Oglesby Cancer Research Building in Withington in Spring 2026.
Applying to intercalate
UoM MBChB students must complete an intercalation Expression of Interest form by 12th January 2026 (we may be able to consider late applications to intercalate in exceptional circumstances). UoM students should contact intercalation@manchester.ac.uk for guidance.
UoL MBChB must apply to intercalate via UoL processes by January 2026.
University of St Andrews Manchester pathway students can contact mcrctraining@manchester.ac.uk for guidance.
Key dates
- Applications open: Monday 20th October 2025
- Applications deadline: Monday 9th March 2026
- Interviews: Week commencing 27th April 2026
- Start date: September 2026
Useful Links
Submit your application
Interested in applying for this opportunity? Submit your application on The University of Manchester application portal.
MB-PhD Studentships
Find out more about our MB-PhD Studentships which allow you to study a fully-funded PhD alongside your medical degree.
Get in Touch
Contact Yasmin Noori, Postgraduate Programme Manager.
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