Regulation of humoral immunity in non-small cell lung cancer

Closing date: 15/03/2027

MB-PhD Studentship: Regulation of humoral immunity in non-small cell lung cancer

Lead Supervisors: Dr Adam Byron
Lead Supervisors: Dr Sean Knight, Professor Angeliki Malliri

Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027

Project Keywords: Lung cancer; Humoral immunity; Tumour microenvironment 
Research Opportunity: MB-PhD Studentship

Project Outline

Lung cancer remains the leading cause of cancer death worldwide. Earlier detection and improved patient stratification are essential for improving outcomes, but this requires a better understanding of how cancer cells interact with their local environment. Lung tumours exist within a complex ecosystem of cancer, immune and support cells that communicate through soluble signalling molecules. These signals help determine how tumours grow, respond to treatment and evade immune surveillance. 

This project focuses on two components of innate immunity, pentraxin-3 (PTX3) and complement component C3, which have emerged from our preliminary work as potential regulators of tumour–microenvironment communication. PTX3 and C3 sit at the interface between inflammation, tissue remodelling and immune responses, making them strong candidates for mediating cellular interactions within lung tumours. However, their precise functions and clinical relevance in non-small cell lung cancer (NSCLC) remain poorly understood. 

The student will combine human lung cancer samples with advanced cellular and co-culture models, molecular biology, spatial transcriptomics, immunology, secretomics and bioinformatics. First, they will identify which cell types produce PTX3, C3 and related humoral-immune signals within lung tumours and determine how these factors are spatially organised. Second, they will investigate how PTX3 and C3 influence communication between cancer cells and immune cells, including soluble signalling pathways that shape inflammatory responses. Finally, they will define extracellular PTX3/C3-centred signalling networks with potential relevance to future biomarker development. 

Our friendly team combines tumour microenvironment biology, systems biology, lung immunology, respiratory medicine and cancer cell signalling expertise. Students will gain interdisciplinary training spanning experimental biology, computational analysis and translational cancer research, while contributing to a clinically relevant project with strong opportunities for publication, collaboration and international training. This provides an exceptional opportunity for an MB-PhD student interested in understanding how fundamental biological discoveries can be translated towards future patient benefit in lung cancer. 

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Dr Adam Byron (project Lead Supervisor)

I am a biochemist and cell biologist at the University of Manchester, where I lead a research group in the Faculty of Biology, Medicine and Health, teach in the School of Biological Sciences and serve as Programme Co-Director for Biochemistry. I am a member of the Manchester Cell-Matrix Centre.

I studied Biochemistry at the University of Warwick and was selected to spend an Intercalated Year of my degree working at AstraZeneca. I received my PhD in Biochemistry from the University of Manchester, where I studied cell adhesion in the laboratory of Professor Martin Humphries, and where I stayed to undertake postdoctoral work. Here, I developed methodologies for the isolation and proteomic analysis of integrin adhesion complexes, which led to the description of the first experimentally defined integrin proteomes and insight into the complexity of the molecular machinery of cell adhesion.

I then moved to the research group of Professor Margaret Frame at the University of Edinburgh, where I used integrative ‘omic approaches to investigate the dysregulation of cell adhesion proteins in cancer. I later took up a Research Fellow position in the Institute of Genetics and Cancer, University of Edinburgh, where my interdisciplinary research developed and implemented proteomic approaches to investigate mechanisms of cancer cell adhesion.

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