Harnessing the nasal proteome for lung cancer early detection

Closing date: 15/03/2027

MB-PhD Studentship: Harnessing the nasal proteome for lung cancer early detection

Lead Supervisors: Professor Tracy Hussell
Lead Supervisors: Dr Sean Knight, Dr Madhvi Menon, Philip Crosbie

Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027

Project Keywords: Early-detection, lung cancer, biomarker 
Research Opportunity: MB-PhD Studentship

Project Outline

Lung cancer causes more deaths than any other cancer because it is diagnosed late when there is no cure. Two landmark clinical trials have demonstrated CT screening scans saves lives by detecting lung cancer earlier when they can be cured. However, CT scans are expensive and involve a radiation exposure, limiting screening to those at the very highest risk and excluding 50-60% people who develop lung cancer. Current screening also requires healthcare contact, which can be a barrier for people living in areas of high deprivation, where lung cancer is most common but healthcare engagement lowest.  

There is an urgent need for accessible, home-based tests for early lung cancer detection. We have discovered and validated a protein signature of lung cancer detectable in the nose using a simple swab that people can self-sample at home. This studentship will develop a scalable test using three complementary approaches: standard controlled mass spec, multiplex ELISA and emerging ELISA technologies such as Alamar Biosciences’ NULISA platform. The student will also determine whether these proteins can identify lung cancer before diagnosis by analysing a unique cohort of 700 people screened for lung cancer 7 years ago. Although all were cancer-free at sampling, 30-40 subsequently developed cancer. This work will advance a scalable, minimally invasive approach to earlier lung cancer detection, with the potential to extend screening to people currently excluded from CT-based programmes.  

The final objective is to understand the mechanisms underlying these nasal protein changes using a novel in vitro platform we have developed. This model enables healthy bronchial epithelial cells to be transformed into cancer and co-cultured with nasal epithelial and immune cells from the same person. This will allow us to investigate how developing cancer alters the nasal environment and identify biological mechanisms driving the protein signature. 

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Professor Tracy Hussell (project Lead Supervisor)

Professor Tracy Hussell is Director of the Lydia Becker Institute with research interests in how the immune system adapts to the changing microenvironment of the tissue. Immune adaptation is relevant to tissues altered by acute events such as severe viral infections as well as chronic conditions including cancer. Her group has defined the molecular cross talk that makes the immune system ineffective, as well as strategies to overcome this. The group is highly published and has a fantastic collaborative ethos, exemplified by the award from the Nature Publishing Group to Hussell of a Lifetime Achievement Award in  mentoring in 2026.

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Tracy Hussell headshot

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