Examining neutrophil heterogeneity in cancer and sepsis

Closing date: 09/03/2026

MB-PhD Studentship: Examining neutrophil heterogeneity in cancer and sepsis

Lead Supervisors: Dr Rebecca Lee
Co-Supervisors:
Prof. Adam Hurlstone, Dr Jamie Weaver, Dr Timothy Cooksley

Applications Deadline: Monday 9th March 2026
Interviews: Week commencing 27th April 2026
Start date: September 2026

Project Keywords: Cancer, sepsis, neutrophils
Research Opportunity: MB-PhD Studentship

Project Outline

Sepsis is an important clinical challenge for patients with cancer. It is associated with 9-12% of all cancer deaths and approximately 20% of sepsis-related admissions in the USA. Cancer patients are associated with significantly poorer outcomes to sepsis than non-cancer patients. We have recently identified a sub-type of neutrophils which occur especially when spread of cancer to the liver is present. These neutrophils are highly immune suppressive and therefore we want to assess whether they affect the ability of the body to respond to infection in patients with cancer. We will also examine whether other neutrophil subsets also contribute to poor sepsis outcomes and assess whether we can target them. You will use a variety of state-of-the-art techniques including flow cytometry, spectral flow cytometry, single cell RNA sequencing, complex co-culture systems and in vivo models to address the questions.

We are looking for a hard-working, focused, ambitious person to join our excellent, friendly, inclusive and collaborative team. Our laboratory makes use of a broad range of in vitro and in vivo techniques, with the aim of developing novel therapies for patients. We closely work with clinicians at The Christie Hospital in Manchester as well as groups both in the UK and internationally to access patient samples and data which feed into our work. We would be particularly happy to receive applications from individuals with a strong academic track record and/or other laboratory research experience in cancer biology.

Our laboratory believes in diversity of thinking, creativity and providing a supportive, kind, joyful environment in which people can flourish. The project will provide comprehensive training in tumour biology and immunology, pre-clinical models and data analysis positioning the candidate for an exciting future as a clinical academic with a foundation of critical reasoning skills which will be essential for their future clinical career.

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Dr Rebecca Lee (project Lead Supervisor)

Dr Rebecca Lee is a senior lecturer in medical oncology at The University of Manchester, The Christie NHS Foundation Trust and a Wellcome early career fellow. Her PhD examined precision medicine approaches to melanoma treatment supervised by Professor Richard Marais and Professor Paul Lorigan. In pre-clinical work, she is examining how local and systemic immune tolerance is induced through interaction between melanoma and cells within the liver microenvironment initially as a post-doc clinical fellow in the laboratories of Prof Erik Sahai and Prof Mala Maini.

She also has developed a number of translational clinical trials to improve outcomes for patients with melanoma. She has now opened her own laboratory at The University of Manchester. This focuses on tumour-host interactions with a particular interest in liver metastases.

Find out more

Becki Lee headshot

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