Cancer as a driver of systemic and organ ageing: mechanisms and trajectories

Closing date: 09/03/2026

MB-PhD Studentship: Cancer as a driver of systemic and organ ageing: mechanisms and trajectories

Lead Supervisors: Dr Amaya Virós
Co-Supervisors:
Dr Jamie Honeychurch, Dr Sara Valpione

Applications Deadline: Monday 9th March 2026
Interviews: Week commencing 27th April 2026
Start date: September 2026

Project Keywords: Cancer, ageing, immunotherapy
Research Opportunity: MB-PhD Studentship

Project Outline

Cancer and ageing are closely linked. Ageing increases the risk of developing cancer, but what is less well understood is whether cancer itself can make the body age faster. Tumours release signals such as inflammatory molecules and metabolic by-products that can damage tissues, trigger cell senescence (“biological ageing”), and disrupt the immune system. These changes resemble those seen in normal ageing and may explain why many cancer survivors experience long-term health problems usually associated with older age. In addition, new cancer treatments such as immunotherapy may also influence ageing processes, but this has not been systematically studied.

This project will ask two questions:
1. Does cancer itself accelerate ageing in different organs and systems of the body?
2. Does immunotherapy alter ageing pathways in ways that could affect long-term health?

To answer this, we will study mouse models of melanoma and breast cancer, comparing tumour-bearing and tumour-free animals. We will track “ageing biomarkers” in blood, tissues, and the gut microbiome over time. These include markers of DNA damage, inflammation, telomere length, mitochondrial function, and immune cell composition. We will also use advanced technologies such as metabolomics, lipidomics, and RNA sequencing to build a detailed picture of how tumours shape ageing. In parallel, we will treat tumour-bearing mice with anti-PD-1/PD-L1 immunotherapy and measure whether this changes ageing signatures. Finally, we will test whether these ageing signals are also present in blood samples from melanoma patients treated with immunotherapy.

The goal is to identify “cancer ageotypes” – patterns of accelerated ageing driven by tumours or therapy – and to develop a blood test that can track them. This work could help doctors monitor the long-term health of cancer survivors, identify patients at risk of early frailty or organ decline, and design interventions to preserve healthy ageing after cancer.

Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.

About Dr Amaya Virós (project Lead Supervisor)

Amaya obtained her medical degree from the University of Barcelona, before her clinical training in Dermatology and Venereology at Vall d’Hebron University Hospital, Barcelona. She became a Fulbright Scholar in dermatology and pathology at the University of California in San Francisco, and later joined the Institute of Cancer Research where she undertook work to complete her PhD with Prof Richard Marais. 

In 2016, Amaya was awarded a Wellcome Intermediate Clinician Scientist Fellowship to develop her research programme that combined her doctoral experience of melanoma with her clinical interest in skin cancer and ageing. In 2023, she was awarded a Cancer Research UK Advanced Clinician Scientist Fellowship. Amaya is an Honorary Consultant in Dermatology at Salford NHS Foundation Trust, with a practice in general dermatology and high-risk skin cancer. 

Find out more

Amaya-Viros headshot

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