Closing date: 15/03/2027
MB-PhD Studentship: Global burden of cancer attributable to elevated body-mass index: an updated analysis including population-specific and Mendelian Randomisation risk estimates, and g-formula impact estimations
Lead Supervisors: Professor Andrew Renehan
Lead Supervisors: Professor Matt Sperrin, Dr Isabelle Soerjomataram, Professor Richard Martin
Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027
Project Keywords: Obesity, cancer incidence, cancer prevention
Research Opportunity: MB-PhD Studentship
Project Outline
Elevated body-mass index (BMI; defined ≥ 25 kg/m²) is associated with increased risk of at least 13 cancer types. In 2026, there is now new evidence, that elevated BMI is associated with up to 19 cancer types; that per increment increase in BMI, risk for some cancers is greater in Asian versus European populations; and risk estimates generated through genetic instruments, namely 2 Mendelian Randomisation (MR) studies, arguably a less biased method, may be larger than those from observational studies. In 2015, the lead supervisor (Renehan) with researchers from IARC (lead: Soerjomataram) estimated that the global population attribution fraction (PAF) on elevated BMI on cancer risk was 3·6%, being greater in women than in men (5·4% vs 1·9%).
Aim: Based on the above new evidence, and the anticipated increased prevalence of elevated BMI worldwide, this thesis will update the 2015 study.
Methods: There will be 3 ambitious workstreams (WSs) – importantly, the statistical algorithms are already available. WS1: PAFs will be derived using update sex- and population-specific relative risks in adults by country, using BMI data freely available from the GBD BMI Collaborator dataset, and extracting incidence data on 19 cancer types from GLOBOCAN2025. WS2: To use the UK Biobank to evaluate time-varying effects of the BMI exposure, including the use of g-formula estimations. WS3: Update the systematic review of MR studies of the associations of BMI traits and susceptibility to cancer and to do a ‘deep drive’ into the controversial aspects of MR study interpretation, relevant to this topic: (i) critical life-stage MR; (ii) directly measured versus genetically proxied measures of BMI; and (iii) selection bias.
Impact: In many western populations, obesity is the second commonest cause of cancer after smoking. This thesis will inform public health policy and future research priorities with contemporary data and updated risk estimates.
Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.
About Professor Andrew Renehan (project Lead Supervisor)
Andrew Renehan is Professor of Cancer Studies and Surgery and leads the Manchester Cancer Research Centre (MCRC) Diabesity and Cancer Research Group, studying relationships between obesity, diabetes, and anti-diabetes therapies, with cancer risk and outcomes – including clinical epidemiology and translational studies. This group is located within the Cancer Screening and Prevention hub at the MCRC Kinnaird Road site and at the Farr Institute@HeRC at Vaughan House on the main University campus. At any one time, he has a team of 1 to 2 postgraduate fellows and 3 to 4 students working on projects in this theme. He is a founder co-chair of the Cancer Prevention Research Network; the bio-statistical lead for biomarker development in the Clinical and Experimental Pharmacology Group, CR UK Manchester Institute; current chair of the European Association for the Study of Diabetes (EASD) Diabetes and Cancer Study Group; co-chair of the MCRC clinical training fellowships scheme. He was one of 21 international scientists in the IARC handbook writing group on obesity and cancer in 2016.
Key information
Find answers to some common questions about our MB-PhD Studentships.
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
- holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
- currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
- holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
- currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria (including English Language).
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of MB-PhD Committee and supervisory team.
The studentship covers:
- An annual stipend of £22,894 per year to help with living costs
- Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates)
- PhD project consumables and running costs, including costs for researcher development such as conferences and travel
- MBChB tuition fees at the UK/home rate (£9,250 per annum) — a total of £37,000 — with a maximum cap of £45,000 per student (plus interest where appropriate
Please speak to the MCRC Training Office regarding individual calculations as these could vary from the stated amount, dependent on how and what fees have been paid. These are conditional upon completion of MBChB and PhD components.
Here are our quick steps to apply for our MB-PhD programme:
1. Eligibility
First, you need to check you are eligible to apply for an MB-PhD. Please see the eligibility tab (below) to read all criteria.
2. Contact supervisors
We encourage you to contact the supervisor of any MB-PhD projects that you are interested in before starting your application. Having these conversations will help you to get a feel for the different research themes and projects on offer.
3. Register
Register to apply for our MB-PhD opportunities using the Postgraduate Application Portal. You must create an account to register.
4. Create a new application
When you create a new application make sure you select the following:
- Academic Career – Postgraduate Research
- Mode of Attendance – Full-time
- Program Description – search for MB-PhD and then select the MB-PhD Programme
- Under ‘Research Title’ list MB-PhD Programme. You can provide supervisor preferences/research interests in your accompanying supporting statement and these will be considered at and after interview. You can apply for a maximum of two projects.
- If you are shortlisted, you’ll be interviewed by our MB-PhD Committee and subject to your interest performance and your project/research preferences will be matched with a lead supervisor.
- For the funding resources section, please include the following information:
– Select ‘Yes’ from the drop-down
– Type of Funding: University of Manchester Scholarship
– Awarding Body: Cancer Research UK MB-PhD
– Status of Funding – Awarded
– Funding Covers – Fully Funded
– Leave the remaining boxes blank
5. Supporting documents
Your application form must be accompanied by a CV and supporting statement. You will also provide referee details (see 6. References). You do not need to add a research proposal, and can ignore this section of the application form, since your lead supervisor will have already produced this to advertise their project.
CV
This should include:
- qualifications (GCSE, A-level or equivalent, and any higher education qualifications, including grades, and your current programme)
- academic prizes, research projects, and academics interests
- extracurricular interests, and activities and positions of responsibility relevant to your application
The information you provide in your CV will be considered in relation to widening participation, and/or university access policies, to ensure that all applicants are treated fairly.
Supporting statement
This should be 1,000 words maximum and include your reason for applying to the MB-PhD programme and your interest and suitability for the project/s you are applying to (maximum two projects). You can include project/research interest/s here and these will be considered at and post-interview.
Supporting documents can be uploaded and submitted with the online application form.
If you have any issues, your supporting documents can be sent directly to the Doctoral Academy Admissions Team at admissions.doctoralacademy@manchester.ac.uk, CC’ing in mcrctraining@manchester.ac.uk.
6. References
You need to list two referees, one of which must be an academic referee from the University of Manchester, University of St Andrews Manchester-pathway or University of Leeds MBChB programme.
This could be a:
- Clinical debrief tutor
- PEP tutor
- Literature research project supervisor
- PPD tutor
Your referees will be automatically contacted by UoM Doctoral Academy when you provide their details upon application. We would recommend notifying them of application timelines in advance.
References cannot be submitted by a supervisor named on the project you are applying for.
7. Acknowledgement and review process
Once you have submitted your application form, we will email you with an acknowledgement.
We will review your application after the application deadline and once we’ve received all your supporting documents. If you are shortlised, you will be invited to attend an interview. If successful at interview, we will also share your application with a nominated supervisor(s) to review.
8. Interviews
We will email you if you are invited to interview.
Interviews will take place at the Oglesby Cancer Research Building in Withington in Spring 2026.
Applying to intercalate
UoM MBChB students must complete an intercalation Expression of Interest form by 15th January 2027 (we may be able to consider late applications to intercalate in exceptional circumstances). UoM students should contact intercalation@manchester.ac.uk for guidance.
UoL MBChB must apply to intercalate via UoL processes by January 2027.
University of St Andrews Manchester pathway students can contact mcrctraining@manchester.ac.uk for guidance.
Key dates
- Applications open: Monday 2nd November 2026
- Applications deadline: Monday 15th March 2027
- Interviews: Week commencing 3rd May 2027
- Start date: September 2027
Useful Links
Submit your application
Interested in applying for this opportunity? Submit your application on The University of Manchester application portal.
MB-PhD Studentships
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