Closing date: 15/03/2027
MB-PhD Studentship: Investigating extracellular matrix stiffness as a risk factor for breast cancer
Lead Supervisors: Professor Sacha Howell
Lead Supervisors: Dr Andrew Gilmore, Dr Hannah Harrison, Dr Hongpeng Zhou
Applications Deadline: Monday 15th March 2027
Interviews: Week commencing 3rd May 2027
Start date: September 2027
Project Keywords: Breast cancer prevention, tamoxifen, extracellular matrix
Research Opportunity: MB-PhD Studentship
Project Outline
Breast cancer (BC) is the leading cause of death for UK women under 50. Around 90% of cases are sporadic, raising questions about the aetiology of genomic damage required to initiate BC. One of the largest risk factors for BC is high mammographic density (MD), determined by the amount of radiopaque tissue seen on a mammogram. regions of high MD are where the collagenous extracellular matrix (ECM) that supports the epithelial ducts is mechanically stiffer.
This elevated ECM stiffness in is directly linked to increased breast cancer risk. Furthermore, recent work from our groups has shown that targeting hormone signalling in high-risk women results in significant remodelling of the periductal and perilobular ECM, in particular collagen isoforms that are associated with MD density and stiffness. Thus, BC risk prevention strategies result in changes in breast ECM composition. However, our mechanistic understanding of how ECM mechanics result in elevated risk is incomplete.
One significant issue around studying ECM and BC risk is the lack of experimental models. Cell culture models allow for modification of ECM mechanics but are simplistic compared to native tissue composition. Mouse models do not recapitulate the collagen rich stromal ECM of human breast, and human tissue biopsies cannot be experimentally manipulated. To overcome these limitations the supervisory team has developed a human breast explant model which can be maintained for up to 14 days in culture, and which retains ECM and tissue organisation.
We will use this model to interrogate how localised changes in ECM composition and mechanics affect cell function and markers of cancer risk. The student will develop approaches for modifying and measuring ECM mechanics within the explant model, and use this to identify target pathways for linking ECM mechanics and cancer risk from our existing spatial transcriptomic data.
Applications for this project are now open. Please complete your application on The University of Manchester Postgraduate Application Portal.
About Prof. Sacha Howell (project Lead Supervisor)
Professor Howell is a Consultant Medical Oncologist specialising in the treatment and prevention of breast cancer. He is director of the Manchester Breast Centre and the Prevent Breast Cancer Research nuit. He trained as a medical oncologist at The Christie, Manchester and gained his PhD studying the role of prolactin in breast cancer stem cell regulation, at the University of Manchester. He has extensive experience in the design and implementation of both cancer treatment and prevention clinical trials.
Professor Howell has developed a platform for the study of preventive approaches through serial breast biopsies and imaging in women at increased risk. Through this approach his team are making significant progress in understanding the mechanisms of action and resistance to existing and novel breast cancer preventive approaches. Through close collaboration with basic scientists in The Manchester Breast Centre, and international collaborators, significant progress is being made in understanding these mechanisms and how mammographic density relates to tissue features, leading to cellular transformation.
Key information
Find answers to some common questions about our MB-PhD Studentships.
To apply to intercalate onto the PhD in Cancer Sciences component of the MB-PhD, you must meet the below criteria and satisfy the general requirements for permission to intercalate set by your institution, including passing all components of the MBChB at first attempt in the year prior to intercalation.
A University of Manchester MBChB student
- holding a BSc (hons) 2.1 or above in a relevant subject and in year 2 or year 3 of the MBChB or year 1 or year 2 of GEM; or
- currently studying in year 3 of the MBChB or year 2 of GEM
A University of St Andrews Medicine BSc (Hons) student on the Manchester course pathway:
- holding or predicted a BSc (hons) 2.1 or above and be intending to intercalate straight onto the MB-PhD ahead of your arrival in Manchester or by no later than between year 3 and year 4 of the Manchester MBChB programme
A University of Leeds MBChB student:
- currently studying in year 3 of the MB ChB
International applicants (including EU nationals) must ensure they meet the relevant academic eligibility criteria (including English Language).
The PhD component of the MB-PhD studentship is usually funded for three years, or four years in exceptional circumstances with prior agreement of MB-PhD Committee and supervisory team.
The studentship covers:
- An annual stipend of £22,894 per year to help with living costs
- Full funding for your PhD tuition fees (at the UK rate, with fee bursaries available for high-performing EU/International candidates)
- PhD project consumables and running costs, including costs for researcher development such as conferences and travel
- MBChB tuition fees at the UK/home rate (£9,250 per annum) — a total of £37,000 — with a maximum cap of £45,000 per student (plus interest where appropriate
Please speak to the MCRC Training Office regarding individual calculations as these could vary from the stated amount, dependent on how and what fees have been paid. These are conditional upon completion of MBChB and PhD components.
Here are our quick steps to apply for our MB-PhD programme:
1. Eligibility
First, you need to check you are eligible to apply for an MB-PhD. Please see the eligibility tab (below) to read all criteria.
2. Contact supervisors
We encourage you to contact the supervisor of any MB-PhD projects that you are interested in before starting your application. Having these conversations will help you to get a feel for the different research themes and projects on offer.
3. Register
Register to apply for our MB-PhD opportunities using the Postgraduate Application Portal. You must create an account to register.
4. Create a new application
When you create a new application make sure you select the following:
- Academic Career – Postgraduate Research
- Mode of Attendance – Full-time
- Program Description – search for MB-PhD and then select the MB-PhD Programme
- Under ‘Research Title’ list MB-PhD Programme. You can provide supervisor preferences/research interests in your accompanying supporting statement and these will be considered at and after interview. You can apply for a maximum of two projects.
- If you are shortlisted, you’ll be interviewed by our MB-PhD Committee and subject to your interest performance and your project/research preferences will be matched with a lead supervisor.
- For the funding resources section, please include the following information:
– Select ‘Yes’ from the drop-down
– Type of Funding: University of Manchester Scholarship
– Awarding Body: Cancer Research UK MB-PhD
– Status of Funding – Awarded
– Funding Covers – Fully Funded
– Leave the remaining boxes blank
5. Supporting documents
Your application form must be accompanied by a CV and supporting statement. You will also provide referee details (see 6. References). You do not need to add a research proposal, and can ignore this section of the application form, since your lead supervisor will have already produced this to advertise their project.
CV
This should include:
- qualifications (GCSE, A-level or equivalent, and any higher education qualifications, including grades, and your current programme)
- academic prizes, research projects, and academics interests
- extracurricular interests, and activities and positions of responsibility relevant to your application
The information you provide in your CV will be considered in relation to widening participation, and/or university access policies, to ensure that all applicants are treated fairly.
Supporting statement
This should be 1,000 words maximum and include your reason for applying to the MB-PhD programme and your interest and suitability for the project/s you are applying to (maximum two projects). You can include project/research interest/s here and these will be considered at and post-interview.
Supporting documents can be uploaded and submitted with the online application form.
If you have any issues, your supporting documents can be sent directly to the Doctoral Academy Admissions Team at admissions.doctoralacademy@manchester.ac.uk, CC’ing in mcrctraining@manchester.ac.uk.
6. References
You need to list two referees, one of which must be an academic referee from the University of Manchester, University of St Andrews Manchester-pathway or University of Leeds MBChB programme.
This could be a:
- Clinical debrief tutor
- PEP tutor
- Literature research project supervisor
- PPD tutor
Your referees will be automatically contacted by UoM Doctoral Academy when you provide their details upon application. We would recommend notifying them of application timelines in advance.
References cannot be submitted by a supervisor named on the project you are applying for.
7. Acknowledgement and review process
Once you have submitted your application form, we will email you with an acknowledgement.
We will review your application after the application deadline and once we’ve received all your supporting documents. If you are shortlised, you will be invited to attend an interview. If successful at interview, we will also share your application with a nominated supervisor(s) to review.
8. Interviews
We will email you if you are invited to interview.
Interviews will take place at the Oglesby Cancer Research Building in Withington in Spring 2026.
Applying to intercalate
UoM MBChB students must complete an intercalation Expression of Interest form by 15th January 2027 (we may be able to consider late applications to intercalate in exceptional circumstances). UoM students should contact intercalation@manchester.ac.uk for guidance.
UoL MBChB must apply to intercalate via UoL processes by January 2027.
University of St Andrews Manchester pathway students can contact mcrctraining@manchester.ac.uk for guidance.
Key dates
- Applications open: Monday 2nd November 2026
- Applications deadline: Monday 15th March 2027
- Interviews: Week commencing 3rd May 2027
- Start date: September 2027
Useful Links
Submit your application
Interested in applying for this opportunity? Submit your application on The University of Manchester application portal.
MB-PhD Studentships
Find out more about our MB-PhD Studentships which allow you to study a fully-funded PhD alongside your medical degree.
Get in Touch
Contact Yasmin Noori, Postgraduate Programme Manager.
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